PlantImRecepV1, Main, Exploration, bibRecord, 000249

Antitumoral and Immunomodulatory Effect of Mahonia aquifolium Extracts.

Identifieur interne : 000249 ( Main/Exploration ); précédent : 000248

Antitumoral and Immunomodulatory Effect of Mahonia aquifolium Extracts.

Auteurs : Andra Diana Andreicu [Roumanie] ; Eva Fischer-Fodor [Roumanie] ; Alina Elena Pârvu [Roumanie] ; Adrian Bogdan Igu [Roumanie] ; Mihai Cenariu [Roumanie] ; Marcel Pârvu [Roumanie] ; Florinela Adriana C Toi [Roumanie] ; Alexandru Irimie [Roumanie]

Source :

Oxidative medicine and cellular longevity [ 1942-0994 ] ; 2019.

RBID : pubmed:31949880

Descripteurs français

KwdFr :
- Activation des lymphocytes (effets des médicaments et des substances chimiques), Activation des lymphocytes (immunologie), Adulte (MeSH), Agranulocytes (anatomopathologie), Agranulocytes (effets des médicaments et des substances chimiques), Agranulocytes (immunologie), Agranulocytes (métabolisme), Apoptose (MeSH), Cellules cultivées (MeSH), Extraits de plantes (pharmacologie), Facteurs immunologiques (pharmacologie), Humains (MeSH), Immunomodulation (effets des médicaments et des substances chimiques), Mahonia (composition chimique), Mouvement cellulaire (MeSH), Mâle (MeSH), Prolifération cellulaire (MeSH), Sous-unité alpha du récepteur à l'interleukine-2 (métabolisme), Tumeurs (anatomopathologie), Tumeurs (immunologie), Tumeurs (métabolisme), Tumeurs (traitement médicamenteux).
MESH :
- anatomopathologie : Agranulocytes, Tumeurs.
- composition chimique : Mahonia.
- effets des médicaments et des substances chimiques : Activation des lymphocytes, Agranulocytes, Immunomodulation.
- immunologie : Activation des lymphocytes, Agranulocytes, Tumeurs.
- métabolisme : Agranulocytes, Sous-unité alpha du récepteur à l'interleukine-2, Tumeurs.
- pharmacologie : Extraits de plantes, Facteurs immunologiques.
- traitement médicamenteux : Tumeurs.
- Adulte, Apoptose, Cellules cultivées, Humains, Mouvement cellulaire, Mâle, Prolifération cellulaire.

English descriptors

KwdEn :
- Adult (MeSH), Apoptosis (MeSH), Cell Movement (MeSH), Cell Proliferation (MeSH), Cells, Cultured (MeSH), Humans (MeSH), Immunologic Factors (pharmacology), Immunomodulation (drug effects), Interleukin-2 Receptor alpha Subunit (metabolism), Leukocytes, Mononuclear (drug effects), Leukocytes, Mononuclear (immunology), Leukocytes, Mononuclear (metabolism), Leukocytes, Mononuclear (pathology), Lymphocyte Activation (drug effects), Lymphocyte Activation (immunology), Mahonia (chemistry), Male (MeSH), Neoplasms (drug therapy), Neoplasms (immunology), Neoplasms (metabolism), Neoplasms (pathology), Plant Extracts (pharmacology).
MESH :
- chemical , metabolism : Interleukin-2 Receptor alpha Subunit.
- chemical , pharmacology : Immunologic Factors, Plant Extracts.
- chemistry : Mahonia.
- drug effects : Immunomodulation, Leukocytes, Mononuclear, Lymphocyte Activation.
- drug therapy : Neoplasms.
- immunology : Leukocytes, Mononuclear, Lymphocyte Activation, Neoplasms.
- metabolism : Leukocytes, Mononuclear, Neoplasms.
- pathology : Leukocytes, Mononuclear, Neoplasms.
- Adult, Apoptosis, Cell Movement, Cell Proliferation, Cells, Cultured, Humans, Male.

Abstract

The prodrug potential of Mahonia aquifolium, a plant used for centuries in traditional medicine, recently gained visibility in the literature, and the activity of several active compounds isolated from its extracts was studied on biologic systems in vitro and in vivo. Whereas the antioxidative and antitumor activities of M. aquifolium-derived compounds were studied at some extent, there are very few data about their outcome on the immune system and tumor cells. To elucidate the M. aquifolium potential immunomodulatory and antiproliferative effects, the bark, leaf, flower, green fruit, and ripe fruit extracts from the plant were tested on peripheral blood mononuclear cells and tumor cells. The extracts exert fine-tuned control on the immune response, by modulating the CD25 lymphocyte activation pathway, the interleukin-10 signaling, and the tumor necrosis-alpha secretion in four distinct human peripheral blood mononuclear cell (PBMC) subpopulations. M. aquifolium extracts exhibit a moderate cytotoxicity and changes in the signaling pathways linked to cell adhesion, proliferation, migration, and apoptosis of the tumor cells. These results open perspectives to further investigation of the M. aquifolium extract prodrug potential.

DOI: 10.1155/2019/6439021
PubMed: 31949880
PubMed Central: PMC6948282

Affiliations:

Roumanie

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Le document en format XML

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<series><title level="j">Oxidative medicine and cellular longevity</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult (MeSH)</term>
<term>Apoptosis (MeSH)</term>
<term>Cell Movement (MeSH)</term>
<term>Cell Proliferation (MeSH)</term>
<term>Cells, Cultured (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Immunologic Factors (pharmacology)</term>
<term>Immunomodulation (drug effects)</term>
<term>Interleukin-2 Receptor alpha Subunit (metabolism)</term>
<term>Leukocytes, Mononuclear (drug effects)</term>
<term>Leukocytes, Mononuclear (immunology)</term>
<term>Leukocytes, Mononuclear (metabolism)</term>
<term>Leukocytes, Mononuclear (pathology)</term>
<term>Lymphocyte Activation (drug effects)</term>
<term>Lymphocyte Activation (immunology)</term>
<term>Mahonia (chemistry)</term>
<term>Male (MeSH)</term>
<term>Neoplasms (drug therapy)</term>
<term>Neoplasms (immunology)</term>
<term>Neoplasms (metabolism)</term>
<term>Neoplasms (pathology)</term>
<term>Plant Extracts (pharmacology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Activation des lymphocytes (effets des médicaments et des substances chimiques)</term>
<term>Activation des lymphocytes (immunologie)</term>
<term>Adulte (MeSH)</term>
<term>Agranulocytes (anatomopathologie)</term>
<term>Agranulocytes (effets des médicaments et des substances chimiques)</term>
<term>Agranulocytes (immunologie)</term>
<term>Agranulocytes (métabolisme)</term>
<term>Apoptose (MeSH)</term>
<term>Cellules cultivées (MeSH)</term>
<term>Extraits de plantes (pharmacologie)</term>
<term>Facteurs immunologiques (pharmacologie)</term>
<term>Humains (MeSH)</term>
<term>Immunomodulation (effets des médicaments et des substances chimiques)</term>
<term>Mahonia (composition chimique)</term>
<term>Mouvement cellulaire (MeSH)</term>
<term>Mâle (MeSH)</term>
<term>Prolifération cellulaire (MeSH)</term>
<term>Sous-unité alpha du récepteur à l'interleukine-2 (métabolisme)</term>
<term>Tumeurs (anatomopathologie)</term>
<term>Tumeurs (immunologie)</term>
<term>Tumeurs (métabolisme)</term>
<term>Tumeurs (traitement médicamenteux)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Interleukin-2 Receptor alpha Subunit</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Immunologic Factors</term>
<term>Plant Extracts</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Agranulocytes</term>
<term>Tumeurs</term>
</keywords>
<keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Mahonia</term>
</keywords>
<keywords scheme="MESH" qualifier="composition chimique" xml:lang="fr"><term>Mahonia</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Immunomodulation</term>
<term>Leukocytes, Mononuclear</term>
<term>Lymphocyte Activation</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Activation des lymphocytes</term>
<term>Agranulocytes</term>
<term>Immunomodulation</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Activation des lymphocytes</term>
<term>Agranulocytes</term>
<term>Tumeurs</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Leukocytes, Mononuclear</term>
<term>Lymphocyte Activation</term>
<term>Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Leukocytes, Mononuclear</term>
<term>Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Agranulocytes</term>
<term>Sous-unité alpha du récepteur à l'interleukine-2</term>
<term>Tumeurs</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Leukocytes, Mononuclear</term>
<term>Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Extraits de plantes</term>
<term>Facteurs immunologiques</term>
</keywords>
<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Tumeurs</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Apoptosis</term>
<term>Cell Movement</term>
<term>Cell Proliferation</term>
<term>Cells, Cultured</term>
<term>Humans</term>
<term>Male</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte</term>
<term>Apoptose</term>
<term>Cellules cultivées</term>
<term>Humains</term>
<term>Mouvement cellulaire</term>
<term>Mâle</term>
<term>Prolifération cellulaire</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">The prodrug potential of <i>Mahonia aquifolium</i>
, a plant used for centuries in traditional medicine, recently gained visibility in the literature, and the activity of several active compounds isolated from its extracts was studied on biologic systems <i>in vitro</i>
 and <i>in vivo</i>
. Whereas the antioxidative and antitumor activities of <i>M. aquifolium</i>
-derived compounds were studied at some extent, there are very few data about their outcome on the immune system and tumor cells. To elucidate the <i>M. aquifolium</i>
 potential immunomodulatory and antiproliferative effects, the bark, leaf, flower, green fruit, and ripe fruit extracts from the plant were tested on peripheral blood mononuclear cells and tumor cells. The extracts exert fine-tuned control on the immune response, by modulating the CD25 lymphocyte activation pathway, the interleukin-10 signaling, and the tumor necrosis-alpha secretion in four distinct human peripheral blood mononuclear cell (PBMC) subpopulations. <i>M. aquifolium</i>
 extracts exhibit a moderate cytotoxicity and changes in the signaling pathways linked to cell adhesion, proliferation, migration, and apoptosis of the tumor cells. These results open perspectives to further investigation of the <i>M. aquifolium</i>
 extract prodrug potential.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">31949880</PMID>
<DateCompleted><Year>2020</Year>
<Month>06</Month>
<Day>29</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>06</Month>
<Day>29</Day>
</DateRevised>
<Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Electronic">1942-0994</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>2019</Volume>
<PubDate><Year>2019</Year>
</PubDate>
</JournalIssue>
<Title>Oxidative medicine and cellular longevity</Title>
<ISOAbbreviation>Oxid Med Cell Longev</ISOAbbreviation>
</Journal>
<ArticleTitle>Antitumoral and Immunomodulatory Effect of <i>Mahonia aquifolium</i>
 Extracts.</ArticleTitle>
<Pagination><MedlinePgn>6439021</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1155/2019/6439021</ELocationID>
<Abstract><AbstractText>The prodrug potential of <i>Mahonia aquifolium</i>
, a plant used for centuries in traditional medicine, recently gained visibility in the literature, and the activity of several active compounds isolated from its extracts was studied on biologic systems <i>in vitro</i>
 and <i>in vivo</i>
. Whereas the antioxidative and antitumor activities of <i>M. aquifolium</i>
-derived compounds were studied at some extent, there are very few data about their outcome on the immune system and tumor cells. To elucidate the <i>M. aquifolium</i>
 potential immunomodulatory and antiproliferative effects, the bark, leaf, flower, green fruit, and ripe fruit extracts from the plant were tested on peripheral blood mononuclear cells and tumor cells. The extracts exert fine-tuned control on the immune response, by modulating the CD25 lymphocyte activation pathway, the interleukin-10 signaling, and the tumor necrosis-alpha secretion in four distinct human peripheral blood mononuclear cell (PBMC) subpopulations. <i>M. aquifolium</i>
 extracts exhibit a moderate cytotoxicity and changes in the signaling pathways linked to cell adhesion, proliferation, migration, and apoptosis of the tumor cells. These results open perspectives to further investigation of the <i>M. aquifolium</i>
 extract prodrug potential.</AbstractText>
<CopyrightInformation>Copyright © 2019 Andra Diana Andreicuț et al.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Andreicuț</LastName>
<ForeName>Andra Diana</ForeName>
<Initials>AD</Initials>
<AffiliationInfo><Affiliation>Pathophysiology, Faculty of Medicine, University of Medicine and Pharmacy Iuliu Hațieganu, RO-400012 Cluj-Napoca, Romania.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Fischer-Fodor</LastName>
<ForeName>Eva</ForeName>
<Initials>E</Initials>
<Identifier Source="ORCID">https://orcid.org/0000-0002-0898-0547</Identifier>
<AffiliationInfo><Affiliation>Medfuture Research Center for Advanced Medicine, University of Medicine and Pharmacy Iuliu Hațieganu, RO-400012 Cluj-Napoca, Romania.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Tumor Biology Department, The Oncology Institute I. Chiricuță, RO--, 400015 Cluj-Napoca, Romania.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Pârvu</LastName>
<ForeName>Alina Elena</ForeName>
<Initials>AE</Initials>
<Identifier Source="ORCID">https://orcid.org/0000-0001-8937-8517</Identifier>
<AffiliationInfo><Affiliation>Pathophysiology, Faculty of Medicine, University of Medicine and Pharmacy Iuliu Hațieganu, RO-400012 Cluj-Napoca, Romania.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ţigu</LastName>
<ForeName>Adrian Bogdan</ForeName>
<Initials>AB</Initials>
<AffiliationInfo><Affiliation>Medfuture Research Center for Advanced Medicine, University of Medicine and Pharmacy Iuliu Hațieganu, RO-400012 Cluj-Napoca, Romania.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Faculty of Biology and Geology, Babeș-Bolyai University, RO-400015 Cluj-Napoca, Romania.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Cenariu</LastName>
<ForeName>Mihai</ForeName>
<Initials>M</Initials>
<Identifier Source="ORCID">https://orcid.org/0000-0001-6501-0128</Identifier>
<AffiliationInfo><Affiliation>Biotechnology Research Center, University of Agricultural Science and Veterinary Medicine, Cluj-Napoca, Romania.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Pârvu</LastName>
<ForeName>Marcel</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Faculty of Biology and Geology, Babeș-Bolyai University, RO-400015 Cluj-Napoca, Romania.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Cătoi</LastName>
<ForeName>Florinela Adriana</ForeName>
<Initials>FA</Initials>
<Identifier Source="ORCID">https://orcid.org/0000-0001-5475-755X</Identifier>
<AffiliationInfo><Affiliation>Pathophysiology, Faculty of Medicine, University of Medicine and Pharmacy Iuliu Hațieganu, RO-400012 Cluj-Napoca, Romania.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Irimie</LastName>
<ForeName>Alexandru</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Oncology, Faculty of Medicine, University of Medicine and Pharmacy Iuliu Hațieganu, RO-400012 Cluj-Napoca, Romania.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2019</Year>
<Month>12</Month>
<Day>14</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>Oxid Med Cell Longev</MedlineTA>
<NlmUniqueID>101479826</NlmUniqueID>
<ISSNLinking>1942-0994</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C508017">IL2RA protein, human</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D007155">Immunologic Factors</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D053645">Interleukin-2 Receptor alpha Subunit</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D010936">Plant Extracts</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017209" MajorTopicYN="N">Apoptosis</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002465" MajorTopicYN="N">Cell Movement</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D049109" MajorTopicYN="N">Cell Proliferation</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002478" MajorTopicYN="N">Cells, Cultured</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007155" MajorTopicYN="N">Immunologic Factors</DescriptorName>
<QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D056747" MajorTopicYN="N">Immunomodulation</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D053645" MajorTopicYN="N">Interleukin-2 Receptor alpha Subunit</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007963" MajorTopicYN="N">Leukocytes, Mononuclear</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008213" MajorTopicYN="N">Lymphocyte Activation</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D028143" MajorTopicYN="N">Mahonia</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009369" MajorTopicYN="N">Neoplasms</DescriptorName>
<QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010936" MajorTopicYN="N">Plant Extracts</DescriptorName>
<QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName>
</MeshHeading>
</MeshHeadingList>
<CoiStatement>The authors declare that they have no conflicts of interest.</CoiStatement>
</MedlineCitation>
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<Month>08</Month>
<Day>23</Day>
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<Month>10</Month>
<Day>31</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2019</Year>
<Month>11</Month>
<Day>02</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2020</Year>
<Month>1</Month>
<Day>18</Day>
<Hour>6</Hour>
<Minute>0</Minute>
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<tree><country name="Roumanie"><noRegion><name sortKey="Andreicu, Andra Diana" sort="Andreicu, Andra Diana" uniqKey="Andreicu A" first="Andra Diana" last="Andreicu">Andra Diana Andreicu</name>
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<name sortKey=" Igu, Adrian Bogdan" sort=" Igu, Adrian Bogdan" uniqKey=" Igu A" first="Adrian Bogdan" last=" Igu">Adrian Bogdan  Igu</name>
<name sortKey=" Igu, Adrian Bogdan" sort=" Igu, Adrian Bogdan" uniqKey=" Igu A" first="Adrian Bogdan" last=" Igu">Adrian Bogdan  Igu</name>
<name sortKey="C Toi, Florinela Adriana" sort="C Toi, Florinela Adriana" uniqKey="C Toi F" first="Florinela Adriana" last="C Toi">Florinela Adriana C Toi</name>
<name sortKey="Cenariu, Mihai" sort="Cenariu, Mihai" uniqKey="Cenariu M" first="Mihai" last="Cenariu">Mihai Cenariu</name>
<name sortKey="Fischer Fodor, Eva" sort="Fischer Fodor, Eva" uniqKey="Fischer Fodor E" first="Eva" last="Fischer-Fodor">Eva Fischer-Fodor</name>
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	Serveur d'exploration sur les récepteurs immunitaires végétaux
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Antitumoral and Immunomodulatory Effect of Mahonia aquifolium Extracts.

Antitumoral and Immunomodulatory Effect of Mahonia aquifolium Extracts.

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